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Some of the controversy about the possible link stems from a study of lab animals reported by the US National Toxicology Program (NTP) in 1990.

The researchers found “equivocal” (uncertain) evidence of cancer-causing potential of fluoridated drinking water in male rats, based on a higher than expected number of cases of osteosarcoma (a type of bone cancer).

In this condition, fluoride collects in developing teeth, preventing tooth enamel from forming normally.

This can cause permanent staining or pitting of teeth.

The types of fluoride added to different water systems include fluorosilicic acid, sodium fluorosilicate, and sodium fluoride.Other possible health effects of fluoridation (positive or negative) are not addressed here.This is not a position statement of the American Cancer Society.Fluorides are compounds that combine the element fluorine with another substance, usually a metal.Examples include sodium fluoride, stannous fluoride, and fluoride monofluorophosphate (MFP fluoride).

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